SHC2 and multiple system atrophy: The combination of CGH-based genome-wide oligonucleotide CNV microarray and CNV beadchip analysis followed by region-targeting, high-density, custom-made oligonucleotide tiling microarray analysis led us to identify copy number loss of SHC2 and its neighboring genes in the 19p13.3 subtelomeric region of the affected MZ twin and 10 (30%) unrelated patients with MSA.