Insulin resistance and hyperglycemia in type 2 diabetes mellitus are associated with a systemic proinflammatory state that promotes the development of atherosclerosis[20,21], as evidenced by increases in the concentration of proinflammatory cytokines, such as IL-6, which plays a deleterious role in the development of CAD and is an early indicator of incipient type 2 diabetes mellitus. The gene discussed is IL6; the disease is diabetes mellitus.