The myxoma growth factor (MGF), also designated M010L, is a secreted virulence factor with similarity to transforming growth factor-alpha and epidermal growth factor (including six conserved cysteine residues involved in Epidermal growth factor (EGF) receptor binding), which is necessary for a successful infection in vivo, although the underlying mechanism is still to be determined [89]. This evidence concerns the gene EGF and infection.