UGT2B7 and cancer: However, in human liver microsomes, genotyped for UGT2B7His268Tyr, no difference related to this polymorphism in epirubicin glucuronide formation was observed [19], but it is conceivable that there is an up- or downregulation of UGT2B7 caused by anti-cancer drug therapy which may differ inter-individually depending on genetic variants.