ESR1 and breast carcinoma: Since many reports have showed the association of genetic variations of estrogen receptor and breast cancer (Iwase H, 1996; Kang et al. 2002; Roodi et al. 1995), it is worthy to presume that the 83 identified SNPs in ER-related genes may very well have either direct or indirect influence on the ER status in breast cancer of different ethnic populations.