IRAK1 has been proposed that one SNP within it, when combined with high-risk genotype at TLR6-1-10, conferred a significant increase in the risk for prostate cancer, suggesting synergistic effects between sequence variants in IRAK1 and the TLR 6-1-10 gene cluster (Sun et al. 2006). This evidence concerns the gene IRAK1 and Familial prostate cancer.