TGFB1 and invasive breast carcinoma: For example, BCAC reported that common coding variants CASP8 D302H in the gene encoding Caspase 8, and TGFB1 L10P in the gene encoding transforming growth factor-β (TGFβ), in one allele (heterozygote) were associated with significant risk to invasive breast cancer (Cox et al. 2007).