CASP8 and breast carcinoma: BCAC also analyzed data from 12 studies for 16 SNPs in various candidate genes and concluded that only 5 SNPS (CASP8 D302H, IGFBP3-202 c > a, PGRV660L, SOD2 V16A, and TGFB1 L10P) were associated with breast cancer, but the statistical significance of the association was only borderline (Breast Cancer Association, 2006).