BCAC also analyzed data from 12 studies for 16 SNPs in various candidate genes and concluded that only 5 SNPS (CASP8 D302H, IGFBP3-202 c > a, PGRV660L, SOD2 V16A, and TGFB1 L10P) were associated with breast cancer, but the statistical significance of the association was only borderline (Breast Cancer Association, 2006). Here, CASP8 is linked to breast cancer.