By analyzing 4,474 breast cancer cases and 4,560 controls from SEARCH collection (United Kingdom), Baynes et al. reported that in contrast to rare variants, the common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 are unlikely to increase the breast cancer risk (Baynes et al. 2007). This evidence concerns the gene BRCA2 and breast cancer.