Examples of such “flip-flop” associations have been previously reported [25], and are well established in ophthalmology for the coding lysyl oxidase-like 1 (LOXL1) variant rs1048661 (R141L) SNP associated with pseudo-exfoliation syndrome in opposite directions in Japanese population compared with Caucasians [26]. The gene discussed is LOXL1; the disease is exfoliation syndrome.