Then the sequence of the promoter region of the PCA3 gene was initially screened for polymorphisms by cloning and sequencing assay in 186 patients with PCa (mean age at diagnosis: 72.33 years; SD: 9.30) and 135 controls (mean age at diagnosis: 71.19 years; SD: 7.39, Table 1). This evidence concerns the gene PCA3 and posterior cortical atrophy.