The functional consequences of an overexpression of these molecules in heart tissue are not known [52], but Bouzeghrane et al. observed an enhanced deposition of fibrillin-1 in the fibrotic hearts of rats suffering from hypertensive disease [53], arguing for a role for fibrillin-1 in myocardial fibrosis. The gene discussed is FBN1; the disease is Myocardial fibrosis.