However, recently several groups reported that Igs could also be produced by non-lymphoid lineage cells [1], including human cancer cells [2], [3], soft tissue tumor cells [4], neurons and glial cells of the central and peripheral nervous system [5], ocular epithelial and ganglion cells [6], mouse testicular spermatogenic cells and epididymal epithelial cells [7] and mouse lactating mammary gland epithelial cells [8]. Here, CUBN is linked to neoplasm.