We further verified E2F1 as a key factor in activating h-eag1 transcription: E2F1-dODN decreased h-eag1 mRNA level by ∼80% in SHSY5Y human neuroblastoma cells (Fig. 1B) and MCF-1 human breast cancer cells (Figure S3). This evidence concerns the gene KCNH1 and neuroblastoma.