Indeed, downregulation of miR-34 has been found in a wide spectrum of tumors [36] in one hand and upregulation of h-eag1 in cancer tissues on the other hand, consistent with h-eag1 being a CNS-localized voltage-gated K+ channel that is ectopically expressed in a majority of extracranial solid tumors [39]. This evidence concerns the gene KCND3 and cancer.