PIRT and dermatitis: There are a number of mouse models to investigate various aspects of medical itch [53]–[58] that can be utilized to see if Pirt plays a role in any facet of itch in its various pathological manifestations such as inflammatory, dermatitis, etc. Our results establish a critical role for Pirt in sensing itch and generate new questions to advance knowledge of itch from both basic science and clinical perspectives.