There are a number of mouse models to investigate various aspects of medical itch [53]–[58] that can be utilized to see if Pirt plays a role in any facet of itch in its various pathological manifestations such as inflammatory, dermatitis, etc. Our results establish a critical role for Pirt in sensing itch and generate new questions to advance knowledge of itch from both basic science and clinical perspectives. This evidence concerns the gene PIRT and skin disorder.