PLAU and neoplasm: The multiple proteases that are expressed at very high levels by either tumor cells, stromal cells or both include urokinase plasminogen activator (uPA), tissue plasminogen activator, matrix metalloproteinase (MMP)-1, -2, -3, -7, -9, -10, -11, -13, and -14, cathepsins B, D, H, and L, kallikreins 5, 7, 8, and 10, and matriptase [11]–[32].