Based on results from the previous study in the Drosophila MYOC-induced ocular hypertension model [11], we selected genes based on three criteria (Table S1): (1) they showed differential expression on Drosophila microarrays (FDR<0.005) [11]; (2) they have human orthologs; and (3) they have known functions in the UPR, ubiquitination, proteolysis, or oxidative-stress pathways [14], [15], [16]. The gene discussed is MYOC; the disease is ocular hypertension.