The ACE levels are highest in individuals with the DD genotype and lowest with the II genotype.[9] It has been shown that the DD genotype is associated with progressive renal dysfunction in diabetic nephropathy and IgA nephropathy.[10, 11] There are few studies evaluating the relationship between steroid responsiveness and ACE gene polymorphism in INS in children.[12–14] Therefore, we studied the distribution of the ACE I/D genotype in children with INS and healthy controls and its association with steroid responsiveness in these patients. The gene discussed is ACE; the disease is diabetic kidney disease.