AGT and glomerulosclerosis: Angiotensin II may contribute to the progression through its action to increase systemic and glomerular blood pressure, proliferation and matrix production by renal cells, tubulointerstitial fibrosis, and glomerulosclerosis.[1, 2] A number of mechanisms have been shown to underlie the pathogenesis of angiotensin II effects on the transglomerular passage of protein.