CFLAR and hepatocellular carcinoma: cFLIP: Cellular FLICE/caspase-8 inhibitory protein (cFLIP), which is an intracellular inhibitor of caspase-8 activation that potently inhibits death receptor-mediated apoptosis, was found to be constitutively expressed in all human HCC cell lines, and was expressed more in human HCC tissues than in non-tumour liver tissues [25].