CD8A and liver disorder: Worsening of liver disease severity (and even mortality in the case of Clo-L treated mice) (Figure S7) was also observed in HBV replication-competent transgenic mice in which all WBC (including PMNs and monocytes) were completely eliminated by whole-body irradiation prior to CD8 T cell transfer (7), reiterating the notion that compensatory functions mediated by liver infiltrating phagocytic cells help KCs at containing liver immunopathology.