rs1957636 (chr14: 53,629,768) is 136 kb upstream of the transcriptional start site of BMP4, 150 kb telomeric to the previously-identified CRC susceptibility SNP, rs4444235 (chr14:53,480,669), which is downstream of BMP4. There is a recombination hotspot at chr14:53,510,000 (Figure S5) and LD between rs1957636 and rs4444235 is very weak (r2 = 0.004, D′ = 0.073 from UK1). This evidence concerns the gene BMP4 and colorectal carcinoma.