Moreover, this study shows that the best results in terms of both objective tumor regression and increased survival time may be achieved when the spiritual approach was associated with a neuroendocrinoimmune chemical therapeutic strategy, such as low-dose IL-2 plus the pineal hormone MLT, carried out to abrogate the main neuroimmune deficiencies occurring in metastatic cancer patients. The gene discussed is IL2; the disease is metastatic malignant neoplasm.