In the same way, pineal indoles other than MLT[21] and the endogenous cannabinoid agonist anandamide may further enhance the anticancer biological response of patients.[22] This statement is justified by the fact that cancer-related immunoneuroendocrine molecular deficiencies are not a simple epiphenomenon associated with tumor dissemination, since their correction through an exogenous administration of the most important molecules responsible for the generation of an effective antitumor neuroimmune response, namely IL-2 and pineal indoles, may induce a control of the neoplastic growth.[23]. This evidence concerns the gene IL2 and neoplasm.