However, extrapolating results from this paper suggests the marker would perform poorly at a population level, such that if 100,000 pregnancies were screened, approximately 5,000 women would be found to have abnormal PAPP-A levels, but of those, only 450 would develop preeclampsia compared to 1,425 among those with normal PAPP-A levels. This evidence concerns the gene PAPPA and preeclampsia.