Moreover, future studies will be required to determine the effect of antiretrovirals on APP proteolysis and microglial Aβ proteases including neprilysin, insulin-degrading enzyme, and endothelin-converting enzymes 1 and 2, as ART modulated proteolytic activity could affect the development of HAND and amyloidosis. The gene discussed is ECE1; the disease is HIV-associated neurocognitive disorder.