The most extreme cohort-independent changes in lifetime survival were observed in Syne1 (HR = 0.17) and Pdcd4 (HR = 4.68), and the former profile has been found in lung [59], ovarian [60], colon, and breast cancers [61]; while, the second has been associated with glioma [62]. The gene discussed is PDCD4; the disease is breast carcinoma.