GPT and Acute hepatitis: This may have been attributed to one patient outlier with pure red cell aplasia who had an absolute increase in serum ferritin levels of >7000 ng/mL from baseline to end-of-study associated with rapid weight loss (5.2 kg over 1 month from treatment day 338–366) and high levels of alanine aminotransferase (ALT) and aspartate aminotransferase (585 and 390 U/L, respectively at treatment day 366), which may have been indicative of acute hepatitis.