The potent p110δ-specific inhibitor CAL-101 exhibits 40- to 300-fold selectivity for that particular isoform, as compared to other PI3K enzymes and is undergoing Phase I clinical evaluation in relapsed or refractory haematological malignancies (CLL, acute myeloid leukaemia, multiple myeloma and non-Hodgkin’s lymphoma) [127]. Here, PIK3CA is linked to non-Hodgkin lymphoma.