Demonstration of inhibition of PI3K signalling, generally using AKTSER473 or RPS6SER240/244 phosphorylation, has also been made in biopsies from solid tumours treated with XL147, GDC-0941, PX-866 and XL765 while a study with the p110δ specific inhibitor CAL-101 reported decreased AKTTHR308 in isolated lymphocytes from CLL patients [117-119,121-127]. Here, PIK3CD is linked to B-cell chronic lymphocytic leukemia.