Importantly, the most potent compound, ME0322, was as efficient as the 17-valent sialic acid–HSA conjugate (Figure 1a).[7] To firmly establish the potential of ME0322 as an anti-adenoviral agent, we evaluated the compound further in a cell-based infection assay (see the Supporting Information).[6, 7, 9] Compound ME0322 proved to be very potent and inhibited the infection of HCE cells by Ad37 virions with an IC50 value of 0.38 μm (Figure 1b). This evidence concerns the gene ALB and infection.