IL10 and infection: In addition, IL-10 production was detected in spleen and lungs after i.n. infection, suggesting that the lack of methylation in the C-terminal domain of HBHA could influence a more complex interplay between Th1 and regulatory type cytokines, in agreement with what has been reported elsewhere concerning the effect of IL-10 on the Th1-type cellular immune response upon vaccination [30, 31].