CXCR3 and primary biliary cholangitis: In addition, there was no significant difference between AMA titers in the serum of WT mice and CXCR3−/− mice, or between different period of PBC, which revealed that the disease severity varied widely among different period mice injected with poly I:C, but did not correlate with AMA titers, both in WT mice and CXCR3−/− mice.