Compared to control model, the proportion of cells positive for CXCR3 was increased in the intrahepatic infiltrates in PBC model, chiefly on CD8+ T cells; furthermore, the proportion of CXCR3+ cells expressed on CD3+ and CD8+ cells was markedly decreased in the splenocytes in PBC model. The gene discussed is CD8A; the disease is primary biliary cholangitis.