CXCR3 and primary biliary cholangitis: In addition, it was reported that CXCR3 and its ligands contributed to the development of necroinflammatory liver damage and progression towards fibrosis in chronic HCV patients [19–28] and other virus-infected liver diseases [29, 30], which implied the possible involvement of chemokine (IP-10 and MIG)-chemokine receptor (CXCR3) interactions in the pathogenesis of PBC [31, 32].