To determine whether distinct subsets of peripheral immune cells are selectively recruited to the liver, we examined the expression of CXCR3 on liver-infiltrating lymphocytes at week 8, 16 and 24 (Figure 4) by flow cytometry which demonstrated a significantly higher proportion of CXCR3 expressed on CD3+, CD4+ and CD8+ cells in liver than in spleen, especially in the WT PBC model mice. Here, CD4 is linked to primary biliary cholangitis.