We, therefore, hypothesized that LPA decreases Taxol-induced accumulation of the cells in G2/M [7] by stimulating Taxol efflux through ABCB1 (multidrug resistance gene 1), p-glycoprotein (ABCC1) or ABCG2, since these transporters account for a major portion of drug resistance in human tumor cells [35]. This evidence concerns the gene ABCG2 and neoplasm.