Primary conventional central chondrosarcoma cells could be then grouped into two main clusters with distinctive marker expression signatures: one group clustering together with mesenchymal stem cells (CD49b-high/CD10-low/CD221-high) and a second group clustering close to fibroblasts (CD49b-low/CD10-high/CD221-low) [37]. The gene discussed is IGF1R; the disease is chondrosarcoma.