In fact, a previously unknown spliced variant transcript of AML1-ETO (AML1-ETO9a) in AML patients encoding a C-terminally truncated AML1-ETO protein, which could induce rapid development of leukemia in murine retroviral transduction-transplantation model, has been identified in a number of AML patients [70]. This evidence concerns the gene RUNX1 and leukemia.