HSP90B1 and Increased total leukocyte count: In comparing our Mx-1-Cre-mediated acute GRP94 KO model with the chimera model using tamoxifen-inducible GRP94 KO following BM transplantation [40], similar hematopoietic phenotypes, including general leukocytosis, increased spleen cellularity, decreased thymus and lymph node cellularities, increased myeloid cells and decreased lymphoid cells in the BM and spleen were observed in both models.