Moreover, due to the observed downregulation of RELB in Hey3Mey2 cells expressing RNASET2, a cell-autonomous role for RNASET2 cannot be completely ruled out, since the RELB protein is known to promote cancer cell survival by inducing the expression of proteins with anti-apoptotic roles, such as Survivin and Bcl-2 [37]. Here, RELB is linked to cancer.