CD4 and cryohydrocytosis: The statistical results showed that the proportion of naïve CD4+T cells were declined in CHC patients compared with HCs (p = 0.0004), while the other three subsets (TCM, p = 0.0480; TEM, p = 0.0015; Effector T, p = 0.0016)were all dramatically increased in CHC patients(Figure 1C).