To molecularly characterize chromosomal aberrations at a high resolution (≤ 20 kb) and compare the genomic features between the MSI-H and MSS subtypes, Affymetrix SNP 6.0 array was applied to detect genome-wide CNAs in 16 MSI-H tumors with both MLH1 hypermethylation and BRAF mutation, and compared to the genomic profiles of 13 MSS CRC tumors. This evidence concerns the gene MLH1 and colorectal carcinoma.