PARK7 and Parkinson disease: There are two potential explanations for the difference between our in vitro and in vivo experiments: 1) In vitro experiment showed the acute responses of the cells to MAP1b overexpression or DJ-1 KD, in contrast, the in vivo study showed the chronic responses of animals to DJ-1 KO; and 2) both environmental and genetic factors are responsible for the pathogenesis of PD.