THBD and Stroke: To further examine whether Solulin’s protective effect after MCAO was because of its anticoagulant activity or mediated by neuroprotective or anti-inflammatory effects described for both thrombomodulin/Solulin and APC, Solulin was administered to FV Leiden mice [14] 60 min after stroke induction, and stroke lesion volumes were evaluated 72 h after MCAO (Fig. 5A).