Wellner et al. showed that the EMT-activator ZEB1 was strongly expressed in less differentiated human pancreatic cancer, and orthotopic (intrapancreatic) injection of Panc1 cells with ZEB1 expression resulted in the formation of a large primary tumor invading into stomach, spleen, small and large bowel, and metastasizing to lymph nodes as well as the liver in nude mice. This evidence concerns the gene ZEB1 and pancreatic neoplasm.