TWIST1 and neoplasm: Mani et al. further demonstrated that the induction of non-tumorigenic, immortalized human mammary epithelial cells into EMT phenotype induced by the expression of either twist or snail, well known transcription repressors, resulted in the loss of epithelial phenotype and the acquisition of mesenchymal phenotype concomitant with the acquisition of CD44high/CD24low expression pattern and increased mammosphere-forming ability as well as tumor initiating capacity [9].