ZEB1 and familial pancreatic carcinoma: Wellner et al. showed that the EMT-activator ZEB1 was strongly expressed in less differentiated human pancreatic cancer, and orthotopic (intrapancreatic) injection of Panc1 cells with ZEB1 expression resulted in the formation of a large primary tumor invading into stomach, spleen, small and large bowel, and metastasizing to lymph nodes as well as the liver in nude mice.