More recently, Gupta et al. also found that the induction of EMT in transformed HMLER breast cancer cells by shRNA-mediated knock-down of E-cadherin expression displayed an increased population of CD44high /CD24low cells, and these cells exhibited a ∼100-fold enhanced mammosphere-forming ability compared to their epithelial phenotypic cells [66]. This evidence concerns the gene CDH1 and breast cancer.