However, tests of interaction between the CRP tertiles and the prognostic factors were all non-significant, suggesting that elevated CRP levels are associated with similarly reduced overall survival irrespective of age at diagnosis, tumour size, lymph node status, presence of distant metastases, tumour grade, and estrogen receptor, progesterone receptor, and HER2 status (Table 3). The gene discussed is ERBB2; the disease is neoplasm.