In summary, our data from multiple approaches in transgenic mice and human normalepithelial and cancer cell lines suggest that OLR1 has severalpro-oncogenic actions based on: a) activation of NF-κB signaling pathwayresulting in inhibition of apoptosis and stimulation of proliferation; b) activationof de novo lipogenesis, and c) more efficient adhesion and transendothelialmigration due to upregulation of OLR1 in endothelium. The gene discussed is OLR1; the disease is cancer.