Although only the Notch, Angiogenesis and Alzheimers disease-presenilin pathways were significantly over-represented (P-value<0.01), the Panther analysis showed that the 68 classified genes represented multiple important signaling pathways such as the Wnt, Cadherin, TGFbeta and Integrin pathways, all known to be important signaling pathways in development. Here, TGFB1 is linked to early-onset autosomal dominant Alzheimer disease.