CFHR4 and systemic lupus erythematosus: In the second largest dataset (1,679 AA cases vs. 1,934 AA controls), four SNPs were significantly associated with SLE (Table 1), all of which confirmed the association detected in EA, with rs16840639, located in the intergenic region between CFHR1 and CFHR4, showing the strongest association signal with a similar effect size (MAF: 37.5% vs. 33.7%, P = 6.6×10−4, OR[95%CI] = 1.18[1.07–1.31]).