I62V (rs800292) located in the N-terminal SCR2 is another well-studied non-synonymous SNP of CFH. Although I62V may result in increased binding of CFH with C3b and enhanced CFH co-factor activity and has been associated with decreased risk of AMD, MPGN II and aHUS [16], [25], it was not associated with SLE in this study (Table S1). This evidence concerns the gene CFH and age-related macular degeneration.