The absence of an association of CFHR3-1Δ with renal disorder in lupus suggests that CFHR3 and CFHR1 play a different role from CFH in the pathogenesis of lupus, although further studies are required to validate the lack of association between the CFHR3-1Δ deletion and renal disorder in SLE. The gene discussed is CFHR1; the disease is systemic lupus erythematosus.