To determine whether CFHR3-1Δ had a stronger association with specific clinical manifestations of SLE, we compared its frequency in SLE cases stratified by the presence or absence of each of the eleven ACR classification criteria (malar rash, discoid rash, photosensitivity, oral ulcers, arthritis, serositis, renal disorder, neurologic disorder, hematologic disorder, immunologic disorder and antinuclear antibody) and five autoantibodies (anti-dsDNA, anti-Sm, anti-RNP, anti-SSA/Ro and anti-SSB/La). The gene discussed is SSB; the disease is nervous system disorder.