In the largest dataset (3,936 EA cases vs. 3,491 EA controls), after removing those failing the Hardy-Weinberg equilibrium (HWE) testing or showing low genotyping quality, fourteen SNPs were significantly associated with SLE (allelic P<0.05) (Table 1), of which rs6677604, located in intron 11 of CFH, exhibited the strongest association signal (minor allele frequency [MAF]: 23.0% in case vs. 20.1% in control, P = 2.4×10−5, OR[95%CI] = 1.19[1.10–1.28]). This evidence concerns the gene CFH and systemic lupus erythematosus.