CFH and atypical hemolytic-uremic syndrome: In recent years, multiple exonic SNPs in CFH, such as I62V, Y402H, D936E and A473A, have been specifically associated with various human diseases including age-related macular degeneration (AMD) [14], [15], atypical hemolytic uremic syndrome (aHUS) [16] and membranoproliferative glomerulonephritis type II (MPGN II) [16], [17] as well as host susceptibility to meningococcal disease [18].