In EA, using rs6677604 as a tag SNP, we found that the homozygous deletion of CFHR3-1Δ conferred a significantly increased risk of SLE (P = 7.5×10−4, OR[95%CI] = 1.47[1.17–1.84]) compared to no deletion, which was stronger than that of the heterozygous deletion (P = 0.0018, OR[95%CI] = 1.17[1.06–1.29]) (Table 3), suggesting a dosage dependent risk effect of the CFHR3-1Δ deletion. The gene discussed is CFHR3; the disease is systemic lupus erythematosus.