In addition, we showed that the underlying causal variant was captured by rs6677104 and rs16840639 and could be localized to a ∼146 kb block extending from intron 9 of CFH to the 5′ region upstream of CFHR4. We demonstrated that the CFHR3-1Δ deletion, which has been associated with AMD and aHUS, could be tagged by the minor risk alleles of rs6677604 (r2 = 1.00 in EA and AS) and rs16840639 (r2 = 0.70 in AA) and showed dosage-dependent association with risk of SLE. This evidence concerns the gene CFH and age-related macular degeneration.