To assess the association of CFH and CFHRs genes with SLE, we genotyped 60 tag SNPs covering the ∼360 kb CFH-CFHRs region in unrelated case-control subjects derived from four ethnic groups including European Americans (EA), African Americans (AA), Asians (AS), and Hispanics enriched for the Amerindian-European admixture (HS) (Figure 1A) (Table S1). Here, CFH is linked to systemic lupus erythematosus.