In these two ethnic groups, we found that only homozygous deletion of CFHR3-1Δ conferred a significantly increased risk of SLE compared to no deletion (AS: P = 0.0021, OR[95%CI] = 3.30[1.47–7.41]; AA: P = 0.0011, OR[95%CI] = 1.40[1.14–1.71]) (Table 3), supporting the hypothesis that homozygous deletion of CFHR3-1Δ conferred a higher risk of SLE than heterozygous deletion. Here, CFHR3 is linked to systemic lupus erythematosus.