In the enlarged AS dataset, we detected the significant association of rs6677604 with SLE (MAF: 7.1% vs. 6.1%, P = 0.0485, OR[95%CI] = 1.19[1.00–1.40]), supporting the hypothesis that CFHR3-1Δ might also be a risk variant for SLE in the AS population. The gene discussed is CFHR3; the disease is systemic lupus erythematosus.