Selected CRC target genes involved in apoptosis (BAX), tumor growth (TGFβRII), WNT pathway (AXIN2, TCF4, WISP3), DNA repair (ATM, ATR, BLM, BRCA1, BRCA2, DNAPKcs, MBD4, MRE11, MSH3, MSH6, RAD50, XRCC2) and PI3-kinase signaling (PTEN) were analyzed for mutations in MSI-positive HGG samples (Table 2). Here, MBD4 is linked to colorectal carcinoma.