Selected CRC target genes involved in apoptosis (BAX), tumor growth (TGFβRII), WNT pathway (AXIN2, TCF4, WISP3), DNA repair (ATM, ATR, BLM, BRCA1, BRCA2, DNAPKcs, MBD4, MRE11, MSH3, MSH6, RAD50, XRCC2) and PI3-kinase signaling (PTEN) were analyzed for mutations in MSI-positive HGG samples (Table 2). The gene discussed is BRCA2; the disease is colorectal carcinoma.