Among 962 subjects from family samples, the lowest plasma adiponectin value was observed in MetS with HTN component (9.3±0.47 μg/ml) compared with that in hypertensives (13.4±0.74 μg/ml) or MetS without HTN (11.9±0.60 μg/ml, P<0.05). The gene discussed is ADIPOQ; the disease is metabolic syndrome.