This approach is illustrated in Figures 5, 6 and 7, wherein suppression of any single molecule (IL-2, IFNγ or TNFα) fails to decrease Teff density in the sarcoidosis phenotype, whereas simultaneous suppression of IL-2 and IFNγ restores the system to the baseline state (i.e., disease remission). The gene discussed is IFNG; the disease is sarcoidosis.