TGF-βs [33] and decorin [34] have beenimplicated as potent tumor suppressors; however, the diverse array of cellularprocesses regulated by TGF-βs seems to depend on the microenvironment: forexample, promoting apoptosis and inhibiting epithelial growth in normal cells andpromoting proliferation and angiogenesis in various cancer models [15], [35]. The gene discussed is DCN; the disease is neoplasm.