In view of the important role of the stroma in epithelial cancers and the role ofdecorin and lumican in tumorigenesis, we tested the hypothesis that inheritedvariation in DCN and LUM may influence the risk ofserous epithelial ovarian cancer in 18 independent study populations: a discoveryset that included studies from Mayo Clinic (MAY) and the North Carolina OvarianCancer (NCO) study, replication set 1 from Australia (AUS), and replication set 2comprised of 12 matched studies from the Ovarian Cancer Association Consortium(OCAC). Here, LUM is linked to ovarian carcinoma.