It has been reported that MPO gene -463G > A polymorphism is related to changes in lipid levels (Nikpoor et al., 2001), and is a mechanism that may be involved in the oxidation of low-density lipoprotein, the high levels of MPO increasing the brittleness of artery plaques, thereby converting the plaque from the stable to the unstable state, thus increasing the risk of acute coronary syndrome (Sugiyama et al.., 2001; Ndrepepa et al., 2008). The gene discussed is MPO; the disease is acute coronary syndrome.