Given the controversy arising from positioning active transcriptional sequences in the periphery of chromosome territories, the aims of the present study were to evaluate spatial intranuclear distribution of CCND1 and HER-2/neu oncogenes within their respective chromosome 11 and 17 territories in esophageal carcinoma, gastric adenocarcinoma and normal mucosae, and to correlate the results so obtained with the gene amplification and protein over-expression status of both the CCND1 and Her-2/neu genes. This evidence concerns the gene CCND1 and gastric adenocarcinoma.