LDLR and familial hypercholesterolemia: Variants in the genes encoding apolipoproteins E (APOE) and B (APOB), as well as the low-density lipoprotein receptor (LDLR), have been associated with hypercholesterolemia and the increased risk of CAD in several populations (Hansen et al., 1993; Series et al., 1993; Ribera et al., 1995; Salazar et al. 1999; 2000; Cavalli et al., 2000; Pongrapeeporn et al., 2000; Guo et al., 2002; Hirashiki et al., 2003; Rios et al., 2003; Souza et al., 2007).