50% of LGMD cases are sarcoglycanopathies related to mutations in SGCA, SGCB, SGCD and SGCG genes, thereby leading to the LGMD2D, LGMD2E, LGMD2F and LGMD2C forms respectively (Guglieri et al., 2005; Daniele et al., 2007). The gene discussed is SGCG; the disease is autosomal recessive limb-girdle muscular dystrophy type 2E.