TIMP2 and glioblastoma: ADAMTS1 negatively regulates tumor growth and metastasis (Vazquez et al., 1999; Luque et al., 2003; Choi et al., 2008) , whereas TIMP2 takes part in degrading ECM (extracellular matrix) and regulating the invasion process (Lu et al., 2004), considered the root cause of the high recurrent incidence in glioblastoma (Kong et al., 2007).